e913ce18fc message . Kamlesh J. The drug is embedded in slow dissolving or erodible matrix or by coating with slow dissolving substance. Comments Posting comment. Rate limiting step is diffusion of drug through inert water insoluble membrane barrier. a) Reservoir b) Matrix Dissolution and Diffusion controlled system.Slide 3: Water penetration controlled system.
Zero order release can be achieved and cleavage of linkage is rate limiting step. TIME LOG CUM.%DRUGHixson Crowell release model: Hixson Crowell release model The equation is, W 0 1/3 - W t 1/3 = ks t Where, W 0 = initial amt of drug W t = remaining amt of drug ks = constant t = time (hrs)Slide 26: The plot of cube root of initial conc. APPLICATION : Used for drug release by dissolution mechanism. In this system the rate controlling step is dissolution. The dissolution rate is depend upon the solubility and thickness of coating.Slide 6: b) Matrix It is also called as MONOLITHS. 425-427, CBS Publishers & Distributors, New Delhi. The wax embedded drug is generally prepared by dispersing drug in molten wax and congealing and granulating same.Diffusion controlled system.: Diffusion controlled system.
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